HOME - ROMANIAN
Tuesday, November 21, 2017   04:46 EET
 
print version

Department of Antiviral Therapy

Relevant Publications

Books

Mihaela Chivu, Molecule matriceale intercelulare în cancer (Extracellular matrix molecules in cancer), chap. Osteopontin, p. 44 – 56, red. Dumitru Miscalencu, Florica Mailat, Edit. Univ. Bucuresti 2003, ISBN 973-575-729-X.

Antivirals, Interferon

Dumitrescu M, Jucu V, Zaharia CN, Belu O, Rojanschi D, Diaconu C, Talos D, Panaitescu M. The action of amphiphilic drugs on human fibroblasts in vitro. Their possible use in antiviral and antitumor chemotherapy. Rev Roum Virol. 1993 Jul-Dec;44(3-4):211-21.

Sahini VE, Dumitrescu M, Volanschi E, Birla L, Diaconu C. Spectral and interferometrical study of the interaction of haemin with glutathione. Biophys Chem. 1996 Feb 8;58(3):245-53.

Diaconu CC, Chitu V, Tardei G, Bleotu C, Ruta SM, Grancea C, Zaharia CN, Cernescu CE, Quantitative semiautomated fluorescence-based assays for biological evaluation of new anti-HIV agents, Cytometry, Wiley-Liss, Inc., ISSN: 0196-476342, 2, p.146, 1 pg., 2000.

Chivu M, Alexiu I, Bleotu C, Rojanschi D, Crisan I, Pop D, Jucu V., Mutiu A., Activitatea antivirala a unor compusi de tip flavonoid de extractie naturala. Actiunea quercetinei asupra multiplicarii virusului herpes simplex in vitro, Studii si cercetari de virusologie 2000, 30 (2): 41 - 47.

Diaconu CC, Volanschi E., Factori celulari implicaţi în rezistenţa multiplă la medicamente – stategii raţionale de evaluare şi chemoprevenţie, Studii şi cercetări de virusologie, 2002, 31, 2, pp.23-34.

Cornitescu M, Chivu M, Cernescu C, Fluorimetric data regarding the combined in vitro action of quercetin and its solvent DMSO on plasma membrane”, Studii si Cercetari de virusologie 2002, 32 (2): 68-73.

Cornitescu M, Chivu M, Cernescu C, Dimethyl sulfoxide prevents the location of quercetin in the cell plasma membrane, Proceedings of the Romanian Academy, 2003, Vol 5, No 1-2, 79-84

Giambasu M, Diaconu CC., Hillebrand M, Electronic Structure Of Some Antiviral Compounds, Internet Electronic Journal of Molecular Design, Bio Chem Press, USA, ISSN 1538-6414, 3, pp. 73 – 82, 10 pg., 2004.

Diaconu CC., Tone M., Ruta SM., Bleotu C., Cernescu C., Volanschi E., Spectral study of the interaction of hemin with some HIV-1 V3 synthetic peptides. Proceedings of the Romanian Academy series B, 2005, vol. 7 (1), 15-22.

Ionescu S, Diaconu CC, Hillebrand M. Theoretical Study of Some Verapamil Derivatives. International Journal of Quantum Chemistry, 2006, JOHN WILEY & SONS INC, 106, 1457-1464

HIV/AIDS

Magureanu C., Diaconu C., Alexandrescu R., Tirdei G., Cernescu C., Studies on the intermolecular forces involved in the antibody- antigen reactions  using V3 synthetic peptides and sera from HIV1 seropositive patients. Rev. roum. Virol., 1994, 45, 143-157.

Târdei G, Duiculescu D, Ruta SM, Jucu V., Diaconu C., Cernescu C., Supravietuirea in vitro a limfocitelor din sângele periferic - un potential marker surogat pentru evolutia infectiei HIV la copii. Studii şi cercetari de virusologie, 27, 35-43, 1997.

Tardei G., Diaconu CC., Ruta SM., Mutiu A., Duiculescu D., Cernescu CE., Microscopic and cytometric evaluation of in vitro zymosan phagocytosis by monocytes from HIV-1-infected children, Romanian Archives of Microbiology and Immunology, ISSN: 1222-3891, 58, 3-4, 332, 1999.

Chitu V, Diaconu CC, Veliceasa D, Ruta S, Grancea C, Tardei G, Cernescu CE. Dynamics of the HIV-1 variability in adults from Bucharest, 1992-1998. Rom J Virol. 1999 Jan-Dec;50(1-4):43-51.

Tardei G, Duiculescu D, Ruta SM, Diaconu CC, Chitu V, Bleotu C, Grancea C, Calistru P, Cernescu C, Investigarea populatiei de limfocite T CD4 pentru aprecierea statusului imunologic al pacientilor HIV pozitivi Comparatie intre metoda mocroscopica rapida si flow citometria standard, Studii şi cercetări de virusologie, 30, 2, pp. 8-17, 10pg., 2000.

Tardei G, Duiculescu D, Capo C, Diaconu CC, Mutiu A, Mege JL, Cernescu CE, In vitro zymosan phagocytosis by monocytes of HIV-infected children, Immunology Letters, Elsevier Science ISSN 0165-247873, 2-3, 179, 2000.

Tardei G., Ruta SM., Diaconu CC., Duiculescu D., Cernescu CE., Microbicidal activity of monocytes in HIV-infected children: The phagosome-lysosome fusion capacity of monocytes is impaired as the disease progresses, Romanian Archives of Microbiology and Immunology, ISSN: 1222-3891, 59, 4, 295-296, 2000.

Tardei G, Duiculescu D, Capo C, Diaconu CC, Mutiu A, Mege JL, Cernescu CE. Phagocytic function of monocytes in children with human immunodeficiency virus type 1 infection.Clin Diagn Lab Immunol. 2000 Mar;7(2):296-7.

HEPATITIS

Cernescu C, Ruta S, Diaconu C, Bleotu C, Grancea C, Truica C, Craciun D, Nedelcu IN. Low rates of seroconversion after hepatitis B vaccination in orphanges with high prevalence of virus carriers. Rom J Virol. 1998 Jan-Dec;49(1-4):73-81.

Constantinescu I, Diaconu C, Grancea C, Bleontu C, Ruta SM, Cernescu C. "Trial moves rapidly on, when the judge has determined the sentence beforehand" (W. Scott: Ivanhoe, 36) or pitfalls in serosurvey of anti-hepatitis C antibody in children. Rom J Virol. 1998 Jan-Dec;49(1-4):11-21.

Ruta SM, Diaconu C, Grancea C, Cernescu C, A survey of hepatitis B virus infection in children from Romanian orphanages, Proceedings of the Romanian Academy, ISSN 1454-8267, Serie B, 1, pp. 67-71, 1999.

STEM/HEMATOPOIETIC CELLS

Chivu M, “Potentialul de diferentiere al celulelor stem pluripotente umane: concepte de baza si definitii”, Studii si Cercetari de Virusologie 2002, 32(2), 1-11.

Chivu M, Carmen C. Diaconu, Lorelei Brasoveanu, Irina Alexiu, Coralia Bleotu, G. Bãnceanu, C. Cernescu, Diferentierea pe linia mieloida a progenitorilor hematopoietici din sângele de cordon ombilical, Studii si Cercetari de Virusologie 2002, 32 (1): 1 - 13.

Chivu M, Diaconu C, Braşoveanu L, Alexiu I, Bleotu C, Bănceanu , Mişcalencu D,  Cernescu C. Ex vivo differentiation of umbilical cord blood progenitor cells in the presence of placental conditioned medium. J. Cell. Mol. Med. 2002, 6:349-359.

Chivu M, Coralia Bleotu, Irina Alexiu, Carmen C. Diaconu, Lorelei Brasoveanu, S. Croitoru, C. Cernescu, Proliferarea celulelor stem hematopoietice în sisteme de cultura ex vivo, Studii si Cercetari de Virusologie 2003, 33 (2): 15.

Chivu M, Diaconu CC, Bleotu C, Alexiu I, Brasoveanu L, Cernescu C.The comparison of different protocols for expansion of umbilical-cord blood hematopoietic stem cells. J Cell Mol Med. 2004 Apr-Jun;8(2):223-31.

Chivu M, Evaluarea impactului a diferite conditii de cultura asupra capacitatii replicative si functionale  a celulelor stem hematopoietice, Studii si Cercetari de Virusologie, 2004, 34 (1):43-48.

Chivu M, Diaconu C. C., Bleotu C., Brasoveanu L., Gheorghiu M., Pasarica D., C. Cernescu, Placental conditioned medium contains growth factors which regulate the development of umbilical cord blood derived stem cells, Proceedings of the Romanian Academy series B, 2004, 2:129-135

Chivu M., Bleotu C., Sultana C., Cornianu-Dragan S., Russu M.C., Nastasia S., Hudiţă D., Cernescu C., Evaluarea impactului unor variabile materne şi obstetrice asupra calităţii sângelui de cordon utilizabil în transplant, Studii si cercetari de virusologie 2005, 35 (1): 3 - 87.

Staerk J, Kallin A, Royer Y, Diaconu CC, Dusa A, Demoulin JB, Vainchenker W, Constantinescu SN.  JAK2, the JAK2 V617F mutant and cytokine receptors. Pathol Biol (Paris). 2006 Aug 10; [Epub ahead of print], PMID: 16904848

PAPILLOMA VIRUSES

Mutiu A, Irina Alexiu, Mihaela Chivu, M. Petica, Gabriela Anton, Coralia Bleotu, Carmen Diaconu, C. Popescu, V. Jucu, C. Cernescu. Detection of human papillomavirus gene sequences in cell lines derived from laryngeal tumors. J. Cell. Mol. Med. 2001, 5:49-59.

Pleşa A., Diaconu CC., Anton G., Repanovici R., ELISA indirectă pentru detecţia anticorpilor neutralizanţi din serul unor pacienţi utilizând antigenul viral recombinat L1 HPV 18, Studii şi cercetări de virusologie32, 2, pp. 61-67, 7 pg., 2002.

Plesa A., Anton G., Diaconu C., Stoian M., Repanovici R., Cernescu C.  - Cloning and expression of the L1 major capsid protein of the human papillomavirus 18 in murine cells - Int. J. Molec. Med. 2003, 12, 1021-1026.

Diaconu CC, Bleotu C, Chivu M, Alexiu I, Petrusca D., Anton G., Achim R., Ruta SM,  Cernescu C. The development of larger cells that spontaneously escape senescence - step during the immortalization of a human cancer cell line. J. Cell. Mol. Med. 2004. 8 (1), 93-101.

Bleotu C., Diaconu CC, Chivu M, Alexiu I, Ruta SM, Cernescu C. Evaluation of TV cell line viral susceptibility using conventional cell culture techniques. Central European Journal of Medicine, 1, 1-11, 2006.

INFLUENZA

Toparceanu F., Bleotu C., Cristea C., Ardeleanu IS., Diaconu CC., Dynamics of cortisol, interleukin-6, and the soluble interleukin-2 receptor in the severe influenza virus infection, European Respiratory Journal, 22, 45, pp.516s, 2003.

OTHERS

Cernescu C, Tardei G, Ruta S, Bleotu C, Alexiu I, Jucu V. An outbreak of aseptic meningitis due to ECHO 30 virus in Romania during the 1999 summer. Rom J Virol. 1999 Jan-Dec;50(1-4):99-106.

Diaconu CC, Szathmari M, Keri G, Venetianer A. Apoptosis is induced in both drug-sensitive and multidrug-resistant hepatoma cells by somatostatin analogue TT-232. Br J Cancer. Nature Publishing Group,1999 Jun;80(8):1197-203.

Diaconu CC, ”Data Mining” in bio-medical research, Studii şi cercetări de virusologie, 31, 1, pp. 21-28, 8pg., 2001.

I.N. Nedelcu, L. Velea, Ruta SM, C. Bleotu, C. Cernescu Semnificatia datelor serologice pentru profilaxia sindromului rubeolos congenital Studii şi cercetări de virusologie 2002,32(1),53-60

Diaconu CC, Szathmari M, Venetianer A., Antiproliferative and apoptosis-inducing effects of hemin in hepatoma cells. Ann N Y Acad Sci. 2003 Dec;1010:311-5.

Van Den Bogaert A, Kaneva R, Schumacher J, De Zutter S, Schulze TG, Becker T, Richter C, Kapur L, Diaconu CC, Ohlraun S, Propping P, Rietschel M, Nöthen MM, Cichon S, Linkage disequilibrium analysis in a susceptibility region for bipolar affective disorder on 8q24, American Journal of Medical Genetics, 2003. Wiley-Liss, USA, ISSN: 0148-7299, 122B/1, 61.

Gheorghiu M, Bara C, Pasarica D, Brasoveanu L, Bleotu C, Toparceanu F, Trandafir T, Diaconu CC. Ethanol-induced dysfunction of hepatocytes and leukocytes in patients without liver failure. Roum Arch Microbiol Immunol. 2004; 63, 5-33.

Paus S, Rietschel M, Schulze TG, Ohlraun S, Diaconu CC, Van Den Bogaert A, Maier W, Propping P, Cichon S, Nothen MM. Systematic screening for mutations in the human N-methyl-D-aspartate receptor 1 gene in schizophrenic patients from the German population. Psychiatr Genet. 2004, 14, 233-234.

Ichim L, Bleotu C, Diaconu CC, Light scattering spectrophotometric device for cellular structure characterization, Proceedings of the Romanian Academy 5, 3, ISSN 1454-8267, pp. 251 - 256, 6 pg, 2004.

Toparceanu F, Alexiu I., Diaconu CC., Bleotu C., Particularităţi ale răspunsului imun şi hormonal în neuroinfecţii virale la copii, Studii şi cercetări de virusologie, 34, 1, 57-61, 5 pg., 2004.

Puiu L., Constantin MC., Simioana MD., Hotnog D., Diaconu CC., Brasoveanu L., Modulation of drug-induced apoptosis in breast cancer cell lines, Anticancer Research ISSN: 0250-7005, 24, 5D, 2004.

Petrusca DN, Petrescu A, Vrabie C, Niculescu L, Jinga V, Diaconu C, Brasoveanu L. Cell cycle regulatory factors in juxta-tumoral renal parenchyma. Rom J Morphol Embryol. 2005, 46, 117-22.

RO EN