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CELLULAR AND MOLECULAR MECHANISMS INVOLVED IN CERVIX SEVERE DISPLASIA REGRESSION (SENCOL–PNCDI 2- 41030

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PHASE 1
Establishment of a tissue/cell base from patients with dysplasia 

[Summary]

CO- (Institute of Virology) and P1 (UMF Iasi- Gynecology Clinic) decided on the inclusion/ exclusion criteria of the patients into the study group.
P1- accomplished patients’ clinical diagnosis and collecting biological samples only after the written approval of the subjects.
CO- realized viral investigations (HPV DNA detection and genotyping, viral load by Real-time PCR, viral status). Cervical explants were used for cell lines initialization. 

68 patients (age 16-60 y o) divided in three category were included in the study group. In CIN1 lesions multiple HPV infections and high HPV levels were noted. By contrast, in CIN3 lesions only single HPV infections with high risk types (16, 18) were observed. In these patients viral loads decreased while the percent of mixed or integrated viral forms increased.


- D. Socolov, AC Anton, G. Anton, R. Socolov, A. Melinte, A. Botezatu, S. Teleman, HPV genotypes distribution in patients with HGSIL cytology , HPV in Human Pathology, Prague, May, 1-3, 2008. Abstract published in Central European J Public Health, 2008, 16 S, 63

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