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CELLULAR AND MOLECULAR MECHANISMS INVOLVED IN CERVIX SEVERE DISPLASIA REGRESSION (SENCOL–PNCDI 2- 41030

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PHASE 2
Study model for senescence/ apoptosis induction in viral transformed cell line cultures [Summary]

[Summary]
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P1- UMF Iasi accomplished patientes clinical diagnosis (27) and collecting biological samples only after the written approval of the subjects.
CO- realized viral investigations

siRNA technology was chosen like experimental model for senescence/ apoptosis induction in  the CaSki and HeLa cell lines. Using E6APsiRNA, we targeted the cellular ubiquitin ligase which facilitateE6 viral oncogene ligation to p53
CO estimated the transfection’ efficiency in Western-blot (for E6AP), in   qReal-Time PCR and flow cytometry for genes involved in phenotype regression (hTERT, p16, p21 and p53)

 

- D Socolov, G Anton, E Anton, S Teleman, AC Anton, A Carauleanu, R Socolov: Distributia genotipurilor virusului papiloma umanla paciente din zona Moldovei; Gineco.ro -a Journal of Obstetrics and Gynecology  2008, 4, ISSN:1841-4435 I
- S. Teleman, D.Socolov, G.Anton, A.C.Anton, C.Ungureanu, A.Melinte, M.Grigore, MS Mihailovici, HPV Testing and follow-up of women with ASCUS/LSIL diagnosis, 34th European Congres of Cithopathology, 15-18 June, Rovaniemi, Finlanda, Abstract published in Cytopathology, 2008, (19) S1,
- Anton G, Brasoveanu L, Botezatu A, Iancu I, Stoian M, Cucu N- SAHA anticancer activity through derepresion effect on critical genes in HPV cell lines- Anticancer Research Conference, KOS-17-23 oct 2008, Abstract published in Anticancer Res, 2008, 28 (5C) p 3198-3199
- Brasoveanu LI, Anton G, Hirt M, Stoian M- Modulation by stimuly tretment of CAM  expression, proliferation and apoptosis associated to cervix tumor cells-  Anticancer Research Conference, KOS-17-23 Oct 2008,  Abstract published in Anticancer Research , 2008, 28 (5C) p 3219
- Anton G,  Bleotu C,  Socolov D, Cornitescu F, Anton AC, Iliescu D, Botezatu A, Teleman S, Goia C, Huica Viral and behavioral markers of HPV persistent infection- EUROGIN-joining forces for cervical cancer prevention, Nice, France, 12-15. Nov 2008 (oral presentation) 

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