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CELLULAR AND MOLECULAR MECHANISMS INVOLVED IN CERVIX SEVERE DISPLASIA REGRESSION (SENCOL–PNCDI 2- 41030

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PHASE 3
Cell pathways involved in senescence/ apoptosis (study on cell culture model) [Summary]

[Summary]

P1- UMF Iasi accomplished patients’ clinical diagnosis and collecting biological samples (39) only after the written approval of the subjects. p16INK4a immunoreactivity on selected samples was investigated
CO realized viral investigations   (HPV DNA detection and genotyping, viral load by Real-time PCR and viral status).
P3 - UMF Bucharest investigated Hsp 70 expression profile in 50 selected biological samples
P2-IC Fundeni used microarray technology for investigating siRNA silenced pathways in a cell culture model accomplished by CO in Phase 2.
siRNA E6AP transfection efficiency varied for CaSki and HeLa cell lines from 28% to 47%. In both cell lines p53 and p21 expression levels increased.

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