Sunday, October 22, 2017   03:57 EET

Bioinformatics and Hardware Group

Project no. 11-034/2007

Nanostructured systems for viral antigens identification
used in medical diagnosis

Project abstract

The main objective of the project is the detection of some pathogenic agents by means of antigen-antibody reactions using nanosystems and inclusion compounds from  cyclodextrine class. For the detection of the hepatitis B, cytomegalic, Epstein-Barr, and human papillomae viruses there will be studied systems with controlled topography aiming their use in medical diagnosis.

For this purpose will be developed imaging techniques using liquid crystals (LC), based on the optical amplification of the perturbations caused by ligand-receptor interactions, and their inclusion in macromolecular nanocavities. These techniques are of high sensitivity and very specific, as alternative to current diagnosis techniques (based on the amplification of the nucleic-acid chains -PCR, and immunoenzimatic assay techniques).

The present project aims to cover the whole research cycle, starting with the preparation of the nanosystems components (design and preparation of nanostructured matrices and of molecular biologic samples), continuing with the detailed investigation of the physical and chemical properties, as well as exploration of systems relevant for the medical diagnostic, and ending by extending the mentioned techniques proposing potential medical applications and biosensors which use the nonlinear optical proprieties of liquid crystals.

By its topic, the project belongs to the thematic area 1.7.6. The present proposal has a multidisciplinary character, creating and consolidating partnerships in the prioritary areas of the Programme 4. aiming to acquire advanced knowledge in the area of clinical laboratory techniques, microbiology, virology, molecular biology, biophysics, condensed-state physics and in particular liquid-crystal physics, fine synthesis and macromolecular chemistry, informatics


Keywords: nanostructures, antigen-antibodies, molecular cavities, liquid crystals, biosensors