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Project

The role of E6/E7 HPV16 oncogenes in chromatin remodelling through components of NuRD complex (MBD2, MBD3)

Project Code: PN-II-RU-TE-2014-4-2502
Acronym: ONCONURD

Phase I: 01/10/2015-30/12/2015
The initiation of cell culture, protocol optimization

Budget: 90.000 lei

Activity I: Cell culture (SiHa), initiation and maintaining of cultured cells
Activity II: Development of HPV 16 E6/E7 oncogene silencing strategy.
Activity III: E6/E7 specific siRNA design and synthesis.

Results- link

1.    Identification of sequences / genes to be blocked and the regions that are targeted by the siRNA designed
2.    In silico analysis of generated siRNA molecules potential (efficiency) and the effects of "off- target" (specificity)

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